Fecal microbiota transplantation among dogs with several different diseases: retrospective cohort study between years 2011-2024

Abstract

Purpose of the retrospective, present study was to determine whether fecal microbiota transplantation (fMt) from well known, otherwise healthy lean donor dogs could be capable of substituting disease condition from disease to health status, reverting to factory settings  and  further might improve the life quality of dogs with several different diseases. Taking into account study design, setting and enrollment (along with accompanying archive data) this clinical trial was conducted between 2011 to 2024 among 1885 diseased dogs with several different system involvement were treated with fMt at median number of 2 to 6 occasions. To those of solely eligible dogs (with witten owner consent, triage position, without systemic inflammatory respond syndrome or other hazardous condition) were recruited for the study. Data were analyzed from March 2011 to June 2024. All fMt interventions from each lean donor (heterologous) were administered either by gastroduodenoscopy (n=112 into the duodenum) or by rectal enema (n= 1773 into the colon). Available cure rates ranged from 41.42% to 93.61% regarding entire enrolled dogs. Forest plot denoted an overall response rate of 76%.  Highest cure rates (nearly 94%) were deemed available for gastroentero-dermatological disorders  to those of satisfactory clinical recovery for each cases enrolled. Lowest cure rates were observed for endocrinological and cardiovascular disease conditions exhibiting 41 and 47%, respectively. Available results were establish future meta-analysis source in which data is lacking. This study should highlighten the efficacy and possible treatment switching modalities to those of uncurable diseases.