The effects of short-term sea buckthorn juice consumption on lipid profile and body composition in hypercholesterolemic women
Keywords:cardiovascular diesease, sea buckthorn juice, lipid profile, cholesterol, body composition
The purpose of this study was to determine whether short-term consumption of 100% sea buckthorn juice (SBJ) affects serum lipids and body composition in hypercholesterolemic women. The study included 31 non-medicated adult women aged 40 to 56 years (average age 49.86 ± 5.98 years). In this intervention study, volunteers received 50 mL of 100% bio commercial SBJ every day for 4-week period. Anthropometric and biochemical parameters were monitored before and after 4 weeks of consumption of SBJ. Body composition was determined using an multifrequency analyzer InBody720. Routine biochemical analyzes were performed by standard methods in an accredited laboratory of the University Hospital by automatic biochemical analyzer BioMajesty JCA-BM6010/C. Supplementation with 100% SBJ increased high-density cholesterol (P <0.05) and decreased low-density cholesterol (P >0.05). There was also a positive decrease in the LDL-C/HDL-C ratio (P <0.01) and C-reactive protein (P <0.001). We observed a significant weight loss (P <0.05), body fat (P <0.01), body mass index (P <0.05) and visceral fat area (P <0.01). The obtained results show that the daily consumption of SBJ for 4 weeks represents a possible prevention of risk factors for cardiovascular diseases (CVD) in hypercholesterolemic women without pharmacotherapy.
Aadil, R.M. et al. (2019). 7 - Functionality of Bioactive [online]. In Nutrients in Beverages. New York: Elsevier BV, 2019, pp. 237-276. ISBN 978-0-12-816842-4. https://doi.org/10.1016/C2017-0-02386-8
Aguirre, L. et al. (2016). Effects of pterostilbene in brown adipose tissue from obese rats. Journal of Physiology and Biochemistry, 73(3), 457–464. https://doi.org/10.1007/s13105-017-0556-2
Bal, L.M. et al. (2011). Sea buckthorn berries: A potential source of valuable nutrients for nutraceuticals and cosmoceuticals. Food Research International, 44(7), 1718–1727. https://doi.org/10.1016/j.foodres.2011.03.002
Barroso, T.A. et al. (2017). Association of central obesity with the incidence of cardiovascular diseases and risk factors. International Journal of Cardiovascular Sciences, 30(5), 416–424.
Beveridge, T. (1999). Sea buckthorn products: manufacture and composition. Journal of Agricultural and Food Chemistry, 47(9), 3480–8. https://doi.org/doi: 10.1021/jf981331m
Bhardwaj, R.L. et al. (2014). Bioactive compounds and medicinal properties of fruit juices. Fruits, 69(5), 391–412. http://dx.doi.org/10.1051/fruits/2014027
Brandhorst, S., Longo, V.D. (2019). Dietary Restrictions and Nutrition in the Prevention and Treatment of Cardiovascular Disease. Circulation Research, 124(6), 952–965. http://dx.doi.org/10.1161/CIRCRESAHA.118.313352
Brown, M.S., Goldstein, J.L. (2006). Biomedicine. Lowering LDL- not only how low, but how long? Science, 2006; 311: 1721–3.
Carmen Zaha, D. et al. (2020). Influence of inflammation and adipocyte biochemical markers on the components of metabolic syndrome. Experimental and Therapeutic Medicine, 20(1), 121–128. http://dx.doi.org/10.3892/etm.2020.8663
Chandrasekara, Shahidi F. (2018). Herbal beverages: Bioactive compounds and their role in disease risk reduction - A review. Journal of Traditional and Complementary Medicine, 8(4), 451–458. http://dx.doi.org/10.1016/j.jtcme.2017.08.006
Chapman, M.J. (2005). The potential role of HDL-and LDL-cholesterol modulation in atheromatous plaque development. Current Medical Research and Opinion, 21, 17–22.
Cheng,T. et al. (1990). Acute toxicity of flesh oil of Hippophae rhamnoides and its protection against experimental hepatic injury. Journal of Traditional Chinese Medicine, 15, 45–47.
Cheng, J. et al. (2003). Inhibitory effects of total flavones of Hippophae Rhamnoides L on thrombosis in mouse femoral artery and in vitro platelet aggregation. Life Sciences, 72(20), 2263–71. https://doi.org/10.1016/S0024-3205(03)00114-0
Chong, M.F.F. et al. (2010). Fruit polyphenols and CDV risk: a review of human intervention studies. The British Journal of Nutrition, 104, S28-S39. https://doi.org/10.1017/S0007114510003922
Christaki, E. (2012). Hippophae rhamnoides L. (Sea Buckthorn): a potential source of nutraceuticals. Food and Public Health, 2(3), 69–72. https://doi.org/10.5923/j.fph.20120203.02
Cohen, J.C. et al. (2006). Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. The New England Journal of Medicine, 354: 1264–72.
Dallmeier, D. et al. (2012). Metabolic syndrome and inflammatory biomarkers: a community-based cross-sectional study at the Framingham Heart Study. Diabetology and metabolic syndrome, 4(1), 28. https://doi.org/10.1186/1758-5996-4-28
Del Pinto, R., Ferri, C. (2018). Inflammation-Accelerated Senescence and the Cardiovascular System: Mechanisms and Perspectives. International journal of molecular sciences, 19(12), 3701. https://doi.org/10.3390/ijms19123701
Drossard, C. et al. (2012). Liking of anthocyanin-rich juices by children and adolescents. Appetite, 58(2), 623–628. https://doi.org/10.1016/j.appet.2012.01.002
Dupak, R. et al. (2022). The consumption of sea buckthorn (Hippophae rhamnoides L.) effectively alleviates type 2 diabetes symptoms in spontaneous diabetic rats. Research in Veterinary Science 152, 261–269. https://doi.org/10.1016/j.rvsc.2022.08.022
Dyrcz, D., Przywara-Chowaniec, B. (2019). Ocena predyspozycji młodych dorosłych do wyst ̨apienia chorób układu kr ̨a ̇zenia. Forum Medycyny Rodzinnej, 13(1), 36–44.
Eccleston C. et al. (2002). Effects of an antioxidant-rich juice (sea buckthorn) on risk factors for coronary heart disease in humans. The Journal of Nutritional Biochemistry, 13(6), 346–354. https://doi.org/10.1016/s0955-2863(02)00179-1
Esmaeili, N.A., Ahmadi, K.J. (2004)). Lipid abnormalities in urban population of Rafsanjan (Rafsanjan coronary risk factors study phase 1). Journal of Diabetes and Metabolic Disorders, 3(0):71-.
Ficzek, G. et al. (2019). Analysis of bioactive compounds of three sea buckthorn cultivars (Hippophaë rhamnoides L. ‘Askola’, ‘Leikora’, and ‘Orangeveja’) with HPLC and spectrophotometric methods. European Journal of Horticultural Science, 84, 31–38.
Gao, Z.L. et al. (2003). Effect of sea buckthorn on liver fibrosis: a clinical study. World Journal of Gastroenterology, 9(7), 1615–7. https://doi.org/10.3748/wjg.v9.i7.1615
German, C.A., Shapiro, M.D. (2020). Assessing Atherosclerotic Cardiovascular Disease Risk with Advanced Lipid Testing: State of the Science. European Cardiology, 15: e56. https://doi.org/10.15420/ecr.2019.18
Graham, I. et al. (2012). Dyslipidemias in the prevention of cardiovascular disease: risks and causality. Current Cardiology Reports, 14:709–720.
Grundy, S.M. et al. (2004). Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines. Circulation, 110: 227–39.
Habanova, M. et al. (2022). Modulation of Lipid Profile and Lipoprotein Subfractions in Overweight/Obese Women at Risk of Cardiovascular Diseases through the Consumption of Apple/Berry Juice. Antioxidants, 11(11), 2239. https://doi.org/10.3390/antiox11112239
Hasani-Ranjbar, S. et al. (2013). A systematic review of anti-obesity medicinal plants - an update. Journal of Diabetes and Metabolic Disorders, 12(1), 28. https://doi.org/10.1186/2251-6581-12-28
Huang, H. et al. (2016). Effects of berries consumption on cardiovascular risk factors: A meta-analysis with trial sequential analysis of randomized controlled trials. Scientific Reports, 6, 23625. https://doi.org/10.1038/srep23625
Jellinger, P.S. et al. (2012). AACE Task Force for Management of Dyslipidemia and Prevention of Atherosclerosis. American Association of Clinical Endocrinologists’ guidelines for management of dyslipidemia and prevention of atherosclerosis. Endocrine Practice, 18(suppl 1):1–78. doi: 10.4158/ep.18.s1.1
Ji, M. et al. (2020). Advanced Research on the Antioxidant Activity and Mechanism of Polyphenols from Hippophae Species-A Review. Molecules, 25(4), 917. https://doi.org/10.3390/molecules25040917
Karimi, F. et al. (2000). The prevalence of hyperlipidemia in persons over 19 years of Bushehr in 1999. Iranian South Medical Journal, 3(2):98–106.
Kähkönen, M.P. et al. (1999). Antioxidant activity
of plant extracts containing phenolic compounds. Journal of Agricultural and Food Chemistry, 47(10), 3954–3962. https://doi.org/10.1021/jf990146l
Kastelein, J.J. et al. (2008). Lipids, apolipoproteins, and their ratios in relation to cardiovascular events with statin treatment. Circulation, 117(23, 3002–3009. https://doi.org/10.1161/CIRCULATIONAHA.107.713438
Kim, S. et al. (2011). Resveratrol exerts anti-obesity effects via mechanisms involving down-regulation of adipogenic and inflammatory processes in mice. Biochemical Pharmacology, 81(11), 1343–51. https://doi.org/10.1016/j.bcp.2011.03.012
Koenig, W. et al. (1999). C-reactive protein, a sensitive marker of systemic inflammation, predicts future risk of coronary heart disease in initially healthy middle-aged men. Results from the MONICA-Augsburg cohort study. 1984–1992. Circulation, 99(2), 237–242. https://doi.org/10.1161/01.cir.99.2.237
Krejcarová, J. et al. (2015). Sea buckthorn (Hippophae rhamnoides L.) as a potential source of nutraceutics and its therapeutic possibilities - A review. Acta Veterinaria Brno, 84(3), 257–268. https://doi.org/10.2754/avb201584030257
Kuhkheil, A. et al. (2017). Chemical constituents of sea buckthorn (Hippophae rhamnoides L.) fruit in populations of central alborz mountains in Iran. Research Journal of Pharmacognosy, 4(3), 1–12.
Kumar, R. et al. (2016). Evidence for current diagnostic criteria of diabetes mellitus. World Journal of Diabetes, 7(17), 396–405. https://doi.org/10.4239/wjd.v7.i17.396
Larmo, P.S. et al. (2013). Effects of sea buckthorn and bilberry on serum metabolites differ according to baseline metabolic profiles in overweight women: a randomized crossover trial. The American Journal of Clinical Nutrition, 98(4), 941–51. https://doi.org/10.3945/ajcn.113.060590
Larmo, P.S. et al. (2009). Effect of a low dose of sea buckthorn berries on circulating concentrations of cholesterol, triacylglycerols, and flavonols in healthy adults. European Journal of Nutrition, 48(5), 277–82. https://doi.org/10.1007/s00394-009-0011-4
Lehtonen, H.M. et al. (2011). Different berries and berry fractions have various but slightly positive effects on the associated variables of metabolic diseases on overweight and obese women. European Journal of Nutrition, 65(3), 394–401. https://doi.org/10.1038/ejcn.2010.268
Luna-Castillo, K.P. et al. (2021). Functional Food and Bioactive Compounds on the Modulation of the Functionality of HDL-C: A Narrative Review. Nutrients, 13(4):1165. doi: 10.3390/nu13041165
Lyons, J.G., O'Dea, K., Walker, K.Z. (2014). Evidence for low high-density lipoprotein cholesterol levels in Australian indigenous peoples: a systematic review. BMC Public Health, 14:545. doi: 10.1186/1471-2458-14-545
Mahmoudi, M. (2018). The Pathogenesis of Atherosclerosis. Medicine, 46(9), 505–508. https://doi.org/10.1016/j.mpmed.2018.06.010
Malinowska, P., Olas, B. (2016). Sea buckthorn-valuable plant for health. Kosmos, 65(2), 285–292.
Marranzano, M. et al. (2018). Associa-tion between dietary flavonoids intake and obesity in a cohort of adults living in the mediterranean area. International Journal of Food Sciences and Nutrition, 69(8), 1020–1029. https://doi.org/10.1080/09637486.2018.1452900
Mozaffarian, D. (2016). Dietary and policy priorities for cardiovascular disease, diabetes, and obesity: a comprehensive review. Circulation, 133(2): 187–225. https://doi.org/10.1161/CIRCULATIONAHA.115.018585
Nuttall, F.Q. (2015). Body Mass Index: Obesity, BMI, and Health: A Critical Review. Nutrition Today, 50(3), 117–128. https://doi.org/10.1097/NT.0000000000000092
Paraíso, A.F. et al. (2019). Oral gallic acid improves metabolic profile by modulating SIRT1 expression in obese mice brown adipose tissue: A molecular and bioinformatic approach. Life Sciences, 237, 116914. https://doi.org/10.1016/j.lfs.2019.116914
Patel, C.A. et al. (2012). Remedial Prospective of Hippophae rhamnoides Linn. (Sea Buckthorn). ISRN Pharmacology, 2012, 436857. https://doi.org/10.5402/2012/436857
Peluso, I. et al. (2014). Consumption of mixed fruit-juice drink and vitamin C reduces postprandial stress induced by a high fat meal in healthy overweight subjects. Current Pharmaceutical Design, 20(6), 1020–4. https://doi.org/10.2174/138161282006140220144802
Prabhu, S.D., Frangogiannis, N.G. (2016). The Biological Basis for Cardiac Repair After Myocardial Infarction: From Inflammation to Fibrosis. Circulation Research, 119(1), 91–112. https://doi.org/10.1161/CIRCRESAHA.116.303577
Rafalska, A., Abramoviwicz, K., Krauze, M. (2017). Sea buckthorn (Hippophae rhamnoides L.) as a plant for universal application. World Scientific News, 72, 123–140. ISSN 2392-2192. https://doi.org/10.3390/ijerph18178986
Ridker, P.M. et al. (2002). C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. The New England Journal of Medicine, 342(12), 836–843. https://doi.org/10.1056/NEJM2o00003233421202
Rodríguez-García, C. et al. (2019). Naturally Lignan-Rich Foods: A Dietary Tool for Health Promotion? Molecules, 24(5), 917. https://doi.org/10.3390/molecules24050917
Rodriguez-Roque, M.J. et al. (2014). In vitro bioaccessibility of health-related compounds as affected by the formulation of fruit juice- and milk-based beverages. Food Research International, 62, 771–778. https://doi.org/10.1016/j.foodres.2014.04.037
Rop, O. et al. (2014). Antioxidant and radical scavenging activities in fruits of 6 sea buckthorn (Hippophae rhamnoides L.) cultivars. Turkish Journal of Agriculture and Forestry, 38(2), article 8. https://doi.org/10.3906/tar-1304-86.
Ruparelia, N., Choudhury, R. (2020). Inflammation and atherosclerosis: what is on the horizon? Heart, 2020, 106(1), 80–85. https://doi.org/10.1136/heartjnl-2018-314230
Sabaka, P. et al. (2012). HDL-cholesterol-relevance in clinical practice. Súčasná klinická prax, 1, 31–35.
Sayegh, M., Miglio, C., Ray, S. (2014). Potential cardiovascular implications of Sea Buckthorn berry consumption in humans. International Journal of Food Sciences and Nutrition, 65(5), 521–528. https://doi.org/10.3109/09637486.2014.880672
Sikora, J. et al. (2012). Short-term supplementation with Aronia melanocarpa extract improves platelet aggregation, clotting, and fibrinolysis in patients with metabolic syndrome. European Journal of Nutrition, 51(5), 549–556. https://doi.org/10.1007/s00394-011-0238-8
Singh, G.M. et al. (2015). Global Burden of Diseases Nutrition and Chronic Diseases Expert Group (NutriCoDE). Global, Regional, and National Consumption of Sugar-Sweetened Beverages, Fruit Juices, and Milk: A Systematic Assessment of Beverage Intake in 187 Countries. PLoS One, 10(8), e0124845. https://doi.org/10.1371/journal.pone.0124845
Soppert, J. et al. (2020). Lipoproteins and lipids in cardiovascular disease: from mechanistic insights to therapeutic targeting. Advananced Drug Delivery reviews, 159, 4–33. https://doi.org/10.1016/j.addr.2020.07.019
Starek, M. et al. (2015). Assay of β-carotene in dietary supplements and fruit juices by TLC-densitometry. Food Analytical Methods, 8, 1347–1355.
Sytařová I. et al. (2020). Impact of phenolic compounds and vitamins C and E on antioxidant activity of sea buckthorn (Hippophaë rhamnoides L.) berries and leaves of diverse ripening times. Food Chemistry, 310, 125784. https://doi.org/10.1016/j.foodchem.2019.125784
Süli, J. et al. (2014). Fyziologické účinky polyfenolov a ich metabolitov v strave - Physiological effects of polyphenols and their metabolites in diet. Československá fyziologie, 63(2), 92–97.
Suryakumar, G., Gupta, A. (2011). Medicinal and therapeutic potential of Sea buckthorn (Hippophae rhamnoides L.). Journal of Ethnopharmacology, 138(2), 268–278. https://doi.org/10.1016/j.jep.2011.09.024
Teleszko, M. et al. (2015). Analysis of Lipophilic and Hydrophilic Bioactive Compounds Content in Sea Buckthorn (Hippophaë rhamnoides L.) Berries. Journal of Agricultural and Food Chemistry, 63(16), 4120–4129. https://doi.org/10.1021/acs.jafc.5b00564
Townsend, N. et al. (2022). Epidemiology of cardiovascular disease in Europe. Nature reviews Cardiology, 19(2), 133–143. https://doi.org/10.1038/s41569-021-00607-3
Turner-McGrievy, G., Mandes, T., Crimarco, A. (2017). A plant-based diet for overweight and obesity prevention and treatment. Journal of Geriatric Cardiology, 14(5), 369–374. https://doi.org/10.11909/j.issn.1671-5411.2017.05.002
Vilas-Franquesa, A., Saldo, J., Juan, B. (2020). Potential of sea buckthorn-based ingredients for the food and feed industry – a review. Food Production, Processing and Nutrition, 2, 2–17.
Wang, L. et al. (2019). Ellagic acid promotes browning of white adipose tissues in high-fat diet-induced obesity in rats through suppressing white adipocyte maintaining genes. Endocrine Journal, 66(10), 923–936. https://doi.org/10.1507/endocrj.EJ18-0467
Wang, Z. (2022). Phytochemistry, health benefits, and food applications of sea buckthorn (Hippophae rhamnoides L.): A comprehensive review. Frontiers in Nutrition, 9, 1036295. https://doi.org/10.3389/fnut.2022.1036295
Wang, K., Xu, Z., Liao, X. (2021). Bioactive compounds, health benefits and functional food products of sea buckthorn: a review. Critical reviews in Food Science and Nutrition, 62(24), 6761–6782. doi: https://doi.org/10.1080/10408398.2021.1905605
Xu, Y.J. et al. (2011). Health benefits of sea buckthorn for the prevention of cardiovascular diseases. Journal of Functional Foods, 3(1), 2–12. https://doi.org/10.1016/j.jff.2011.01.001
Yang, B., Kallio, H. (2002). Supercritical Co-extracted sea buckthorn (Hippophaë rhamnoides) oils as new food ingredients for cardiovascular health. Proc. Health Ingred. 2002, 17, 7.
Yu, E., Malik, V.S., Hu, F.B. (2018). Cardiovascular disease prevention by diet modification: JACC Health Promotion Series. Journal of the American College of Cardiology, 72(8), 914–926. https://doi.org/10.1016/j.jacc.2018.02.085
Zou, Y. et al. (2021). LDL/HDL cholesterol ratio is associated with new-onset NAFLD in Chinese non-obese people with normal lipids: a 5-year longitudinal cohort study. Lipids in Health and Disease, 20(1), 28. https://doi.org/10.1186/s12944-021-01457-1
Copyright (c) 2023 Ing. Jana Kopčeková, PhD., Jana Mrázová, Katarína Fatrcová-Šramková, Kristína Jančichová, Maroš Bihari, Peter Chlebo, Július Árvay
This work is licensed under a Creative Commons Attribution 4.0 International License.