Effect of FTO rs1121980 to Body Mass Index

Abstract

The aim of this study is to investigate the effect of selected polymorphism FTO rs1121980 on body mass index in humans. In the study participated 79 people from Slovakia with some genetic relatedness. We used column kit to isolate the genomic DNA from a buccal swab. Genotyping of single nucleotide polymorphism rs1121980  of FTO gene was performed by amplification-refractory mutation system (ARMS). The most common genotype was found in heterozygous form (CT=0.4051). The FTO gene had increased frequency of T allele (0.50635). The least frequent genotype in FTO was CC (0.2911). According to the results we can assume that the genotype CC (FTO rs1121980) has a protective effect on the prevalence of obesity compared to the other genotypes. With adding of the anthropometric measurements, blood test and extension of the group, we could in the future increase the statistical relevance in relation to obesity.